Diagnostic imaging, cardiology

CT angiography highly accurate in detecting coronary artery disease

29 November 2007

Computed tomography (CT) angiography is as accurate as an invasive angiogram in detecting coronary artery disease, according to the findings of the first two prospective metacentre 64-slice scanner trials presented at the annual meeting of the Radiological Society of North America (RSNA).

"These two trials with comparable results clearly set the stage for the widespread adoption of and reimbursement for coronary artery CT examinations," said Gerald D. Dodd III, M.D., chair of the Department of Radiology at the University of Texas Health Science Center in San Antonio.

For the CORE-64 Trial (Coronary Artery Evaluation Using 64-Row Multidetector Computed Tomography Angiography), researchers at nine international centres studied 291 patients who were scheduled to undergo invasive coronary angiography for suspected or unknown coronary artery disease. The study found that 64-slice multidetector CT angiography was highly accurate in detecting blockages of greater than 50%, with a sensitivity of 85% and a specificity of 90%. The noninvasive exam was equal in accuracy to invasive angiography in its ability to identify patients to be referred for angioplasty or bypass surgery.

"Reliable assessment of the presence of coronary blockages and accurate prediction of coronary revascularizations are feasible with 64-slice CT coronary angiography," said presenter Marc Dewey, M.D., radiologist at Humboldt University Berlin, Charité, Germany. "Patients with low to intermediate risk of having coronary blockages are most likely to benefit from coronary CT angiography, since in those patients the necessity of invasive angiography is greatly reduced."

The ACCURACY Trial (assessment by coronary computed tomographic angiography of individuals undergoing invasive coronary angiography) compared 64-row coronary computed tomographic angiography (CCTA) to quantitative coronary angiography (QCA). The results demonstrated that CCTA is highly accurate in detecting coronary blockages in chest pain patients referred for invasive coronary angiography and is also an effective noninvasive method to exclude obstructive coronary blockages.

Sixteen institutions performed CCTA on 232 patients with typical or atypical chest pain prior to invasive coronary angiography. Findings were then compared to those of QCA, the reference standard used to quantify the results of the invasive coronary angiography.

A total of 82 blockages greater than 50% in 49 patients and 31 blockages greater than 70% were detected in 28 patients by QCA. Per-patient sensitivity and specificity of CCTA were 93% and 82%, respectively, for blockages greater than 50%, and 91% and 84% for blockages greater than 70%. In addition, negative predictive value was 97 to 99%.

"In a population of chest pain patients with a low to intermediate prevalence of obstructive coronary artery blockages, CCTA performed highly accurately compared to invasive coronary angiography," said presenter James K. Min, M.D., assistant professor of radiology and medicine at New York Presbyterian Hospital and director of the Cardiac Computed Tomography Laboratory and Cornell University Medical Center. "These findings demonstrate the high diagnostic performance of CCTA."

Further information

The 2007 meeting of the Radiological Society of North America (RSNA): http://rsna2007.rsna.org

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