ExonHit Therapeutics expands strategic collaboration with Allergan

16 January 2009

Paris-based ExonHit Therapeutics (Alternext: ALEHT) has announced a reinforcement of its existing drug discovery collaboration with Allergan Sales, LLC (NYSE: AGN). The collaboration, which is extended until December 2011, includes antibody discovery within the scope of the research activities and encompasses revised commercial terms. Detailed financial terms were not disclosed.

The collaboration focuses on the identification, development and commercialization of drugs for the treatment of neurodegenerative diseases, pain and ophthalmology. EHT/AGN 0001, the most advanced compound out of the collaboration, is currently ending Phase I clinical trials for pain indications. EHT/AGN 0002 and other compounds are in pre-clinical testing for indications in pain, ophthalmology or neurodegenerative diseases.

As part of the renewal agreement, Allergan will provide ExonHit with increased quarterly research funding instead of a single payment.

The scope of the collaboration is expanded to include epitope* discovery for the development of antibody therapeutics in ocular disorders. ExonHit's unique gene profiling technology can readily be applied to identify disease specific target proteins, but also pinpoints novel epitopes present in those proteins, which are produced via alternative splicing.

ExonHit's approach offers the potential benefit of identifying epitopes that are particularly disease specific, thus enabling the discovery of safer drugs with fewer side effects. In addition, such epitopes may provide the opportunity to create new intellectual property, even in more heavily investigated areas.

"We are very pleased to expand further our successful and longstanding collaboration with Allergan. We believe that combining the capabilities of our two organizations and enlarging both the research and commercial scope will enhance our ability to create value for our shareholders," said Loic Maurel, CEO of ExonHit Therapeutics.

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