Optical coherence tomography shows effect of drug delivery by
microneedles
21 Oct 2010
Researchers at Queen’s University Belfast have studied the
performance of microneedles for drug delivery using an optical coherence
tomography system from Michelson Diagnostics (MDL).
The research, published in the Journal of Controlled Release
[1], shows how the MDL VivoSight OCT system was used to directly
image the microneedles penetrating the skin, and how the results
were used to evaluate the effects of microneedle spacing and force
of application.
OCT image of microneedles penetrating the skin
Drug delivery systems using microneedle arrays are of great
interest to pharmaceutical companies who would like to alleviate the
discomfort of the standard hypodermic needle with
an-easy-to-administer, painless drug delivery method. Many companies
are developing microneedle technology, targeting a slice of the
$18bn drug delivery device market. The microneedles range from
hollow or coated steel arrays to biodegradable polymer needles that
dissolve once injected.
Microneedle developers aim to design devices that are effective
at penetrating the surface layer of skin, known as the stratum
corneum, to deliver drugs to the dermis, whilst being short and
narrow enough to avoid stimulating the dermal nerves and causing
discomfort. It is important to understand how a change in
microneedle design and application method affects the device
performance.
According to the authors of the paper, “The successful use of OCT
in this study could prove to be a key development for polymeric
micro-needle research, accelerating their commercial exploitation.”
“The VivoSight system is a unique tool for transdermal drug
delivery development. It is the only clinical technology that can
image the needles in situ, in real time,” said Dr Daniel
Woods, Senior Imaging Scientist at Michelson Diagnostics Ltd.,
adding “The high resolution and extended penetration depth of
VivoSight mean that researchers can really understand how the
needles interact with the skin.”
Reference
1. Ryan F. Donnelly, Martin J. Garland, Desmond I.J. Morrow,
Katarzyna Migalska, Thakur Raghu Raj Singh, Rita Majithiya, A. David
Woolfson. Optical coherence tomography is a valuable tool in the
study of the effects of microneedle geometry on skin penetration
characteristics and in-skin dissolution. Journal of Controlled
Release. DOI:10.1016/j.jconrel.2010.08.008