Nanion starts shipping SyncroPatch 384PE drug screening system

1 October 2013

Nanion's SyncroPatch 384 Patch Engine (PE) is designed for seamless integration into process-automated drug screening environments.

It is equipped with 384 patch clamp amplifiers and an advanced 384 channel liquid handling robot.

The SyncroPatch 384PE is the high quality, automated patch clamp system for primary ion channel drug screening. Allowing for up to 20,000 data points per day, it is the most efficient platform on the market for high quality, ion channel recordings. This efficiency is primarily due to fully parallel measurements from 384 cells, the 384-channel pipettor, and an efficient control and analysis software. Both hardware and software have been fully tested and validated with leading players in industrial ion channel drug development to provide optimum performance in true HTS for ion channel screening.

The Patch Engine is a modular approach specifically designed for integration with all aspects of process-automated screening environments. Up to two of the 384 channel patch clamp modules can be integrated into one liquid handling robot, enabling 768 recording wells to be measured simultaneously. Success rates are routinely over 85%, and liquid consumption is low. A full run of 384 cells for dose response analysis takes less than 15 minutes, delivering several thousand data points per hour.

Dr. Niels Fertig, CEO of Nanion sais, “The SyncroPatch 384PE is a landmark in the history of automated patch clamping. It follows a completely revolutionary concept: a truly modular and HTS-capable automated patch clamp device that will integrate into your existing or planned screening process line, rather than being a closed, stand-alone system.

"No other platform on the market is capable of recording 384 to 768 cells in parallel, let alone with giga-seals. In development, we have carefully listened to key customers from industrial pharma high throughput screening laboratories to fulfil their requirements of HTS-settings.“